Protein Purification System
AutoPure protein chromatography purification system
AutoPure is a highly flexible modular protein chromatography system that can be used for rapid purification of target products such as proteins, peptides, and nucleic acids from micrograms to grams.
The main components of AutoPure are selected from well-known domestic and foreign manufacturers , with excellent performance and reliable quality. The parts in contact with the sample are all biologically inert materials, which have good compatibility with biological samples and will not pollute or damage the sample.
The AutoPure system supports various chromatography technologies to meet the automation requirements of users for this type of equipment. The system configuration is flexible and can be upgraded at any time according to needs to further improve its performance.
Application field
- Peptide purification
- Vaccine purification
- Monoclonal antibody purification
- Recombinant protein purification
- Gene therapy drug purification
- Separation and purification of blood products and polysaccharides
Product description
- Double plunger binary gradient pump, the pump head is made of PEEK material, with self-flushing function, to avoid the wear of the plunger caused by the precipitation ;
- All valves, detectors and chromatographic columns are installed facing the operator, which is convenient for users to clearly and intuitively understand the relationship between various modules and the flow paths of samples and buffers.
- Wide detection range meets the maximum absorption of different samples, from fixed wavelength detector to variable multi-wavelength detector.
- Equipped with PH and conductivity detectors for real-time monitoring, and can perform temperature compensation for PH and conductivity as needed.
- Fully automatic fraction collector, equipped with various collection racks, supports multiple collection methods, realizes full automation of collection and liberates manpower.
- Humanized software design, can provide Chinese and English operation interface interchangeable, simple operation, powerful function; software Logbook records the whole process, you can check all the operations of the software at any time.
- It meets the requirements of GMP /GLP regulations and FDA/CFDA regulations. It has functions such as user authority settings, audit trails, and electronic signatures, ensuring data reliability and security.
Software Function
- Real-time collection and display of instrument chromatographic detector signal, pressure, flow rate, gradient, valve closing status and other data
- Log records manual or method operations, system errors, and warning light information, which is convenient for viewing and operation traceability.
- The flow diagram can dynamically display the flow state of the chromatographic system in real time.
- During the running of the method, manual commands can be used, such as modifying the flow rate, gradient, collection conditions, etc., to make the instrument run the new method again.
- Advanced integral algorithm minimizes the error caused by integral.
- The method editing management module adopts the advanced UI+script mode, and the editing function is powerful, so that the method can be run while analyzing, and the method can be modified in real-time.
- The report management mode contains the standard format of key points and has the report format editing function, and the user can freely edit and store the report format.
- A closed system with functions such as user authority settings, audit trails, and electronic signatures, and complies with FDA 21CFR, Part11 /GLP / GMP, and other relevant regulations.
- Network server database management function, data can be backed up regularly, which effectively guarantees the security of data.
Chromatography Workstation
UniqueCDSystem Chromatography Workstation is a powerful, advanced and stable chromatographic data management system that integrates instrument control, method management, data analysis, standard curve, report editing, user rights management and network database functions. Comply with FDA 21CFR, Part11 /GLP / GMP and other relevant regulations, and meet the requirements of the pharmaceutical industry for data traceability and security.
Product Description
system characteristics
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Basic Features |
mixer |
system pump |
valve |
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System Control: Unique CDSystem Chromatography Workstation |
Mixing principle: magnetic stirring mixing chamber |
Pump Type: Piston Pump |
Valve Type: Rotary Valve |
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Size: 360*500*450mm |
Mixing volume: 2ml (standard), or 5ml |
Flow rate range: 0.001-50ml/min |
Quantity: up to 10 |
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Weight: 38Kg |
Gradient flow rate range: 0.001-50ml/min |
0.001-100ml/min |
Function: standard – sample valve (three-position seven-port valve) |
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Power supply: 100-240V, 50-60Hz |
0.001-100ml/min |
0.01-300ml/min |
Optional: column valve, collection valve, ten-channel Buffer |
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Environment: temperature range 2-40℃ |
0.01-300ml/min |
Flow rate accuracy: ±1.2% |
module, four-channel Buffer selection module, etc. |
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Relative humidity <90% (non-condensing) |
Gradient accuracy: 0.5%RSD |
Pressure range: 4000psi, 1500psi, 500psi | |
| Enclosure rating | Gradient type: linear, isocratic, gradient can be modified online |
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UV detector |
PH/conductivity detector | fraction collector |
| Detector model: standard configuration 200-400nm, detect 2 wavelengths at the same time, including 2mm external flow cell, typical lifespan 4000H; | PH detection: detection range 0-14, accuracy ± 0.1 | Collection method: valve collection, collection rack collection |
| Optional 200-600nm, simultaneously detect 4 wavelengths; 190-840nm, simultaneously detect 4 wavelengths; | Operating pressure: 0-0.5Mpa (75psi) | Collection modes: signal collection, fixed volume collection, order |
| 254/280nm, fixed single wavelength | Conductivity detection: detection range 0.001-999.99mS/cm | Segment signal collection, stage time collection, |
| Wavelength accuracy: ±1nm | Accuracy ±2% | conductance collection, etc. |
| Noise range: ±0.4×10-3AU (1s) | Temperature compensation: 2-100°C, accuracy ±0.5°C | Collection quantity: 2 collection tubes with a diameter of 16mm (15ml) |
| Flow cell: standard 2mm external flow cell |
Purchase Information
AutoPure protein chromatography purification system (standard configuration) |
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Infusion Pump |
model |
AutoPur50 _ |
AutoPur 100 _ |
AutoPur 300 _ |
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material |
Binary double plunger PEEK pump, biologically inert material, high precision, high pressure resistance |
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flow rate |
0.001-50ml /min |
0.001- 10 0 ml/min |
0.01- 300 ml / min |
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pressure |
2 000psi |
1500psi |
500psi |
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Detector |
model |
UVF280 |
DAD402 |
DAD604 |
DAD804 |
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wavelength |
280nm |
200-400nm |
200-600nm |
200-800nm |
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aisle |
one |
pair |
Four |
Four |
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mixer |
2ml dynamic mixer cavity, liquid mixing is more complete |
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Bubble sensor |
Induction and monitoring of sample air bubbles |
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Injection valve |
Three-position seven-way valve, supporting Load, Inject, Waste |
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pH detector |
Detection range: 0-14, accuracy ±0.1 |
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Conductivity detector |
Detection range: 0.001-999.99 mS/cm , accuracy ± 2%; accuracy compensation range: 2-100°C, accuracy ± 0.5 °C |
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Chromatography Workstation |
Workstation software, branded computer, genuine Win7 operating system, communication adapter module, etc. |
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Toolkit |
PEEK/ PTFE pipe, installation manual, user manual, fittings, common tools, etc. |
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AutoPure protein chromatography purification system ( select configuration) |
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flow cell |
5mm or 10mm optical path optional |
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mixer |
0.6ml, 5ml or 10ml dynamic mixer chamber optional |
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Mobile Phase Selection Module |
Four-channel mobile phase selection module (A1 /A2 , B 1 /B2 four mobile phases) |
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column valve |
Support Column and ByPass functions; support column recoil |
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collection valve |
Large volume sample collection (5 sample collection channels, 1 waste liquid channel) |
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Column selection module |
Option of 5 columns and ByPass |
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Ten-channel Buffer module |
Buffer solution of 10 channels can be selected |
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fraction collector |
1. 50ml /30mm ID collection rack, can hold 21 collection tubes |
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2. 1 5ml / 16 mm ID collection rack, can hold 60 collection tubes |
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3. 8 ml / 1 3mm ID collection rack, can hold 90 collection tubes |
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4. 1.5ml / 2.5ml / 5ml / 96 -well plate |
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column bracket |
Optionally place 1ml, 5ml, ID10, 16, 26, 50mm chromatography columns |
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